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| Ran, N.; Draths, K. M.; Frost,
J. W. "Creation of a Shikimate Pathway Variant."
J. Am. Chem. Soc. 2004, In press. |
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| Guo, J.; Frost, J. W. "Synthesis
of Aminoshikimic Acid." Org. Lett. 2004, 6,
1585. |
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| Zha, W.; Shao, Z.; Frost, J.
W.; Zhao, H. "Rational Pathway Engineering
of Type I Fatty Acid Synthase Allows the Biosynthesis
of Triacetic Acid Lactone from D-Glucose in Vivo."
J. Am. Chem. Soc. 2004, 126, 4534 |
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| Chang, Y.-C; Almy, E. A.; Blamer,
G. A.; Gray, I. A.; Frost, J. W.; Strasburg, G. M. "Antioxidant
Activity of 3-Dehydroshikimic cid in Liposomes, Emulsions,
and Bulk Oil." J. Agric. Food Chem. 2003, 51, 2753. |
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| Chandran, S. C.; Yi, J.; Draths, K. M.; von Daeniken,
R.; Weber, W.; Frost, J. W. "Phosphoenolpyruvate Availability
and the Biosynthesis of Shikimic Acid." Biotechnol.
Prog. 2003, 19, 808. |
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| Yi, J.; Draths, K. M.; Li, K.;
Frost, J. W. "Altered Glucose Transport and Shikimate
Pathway Product Yields in E. coli." Biotechnol. Prog.
2003, 19, 1450. |
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| Niu, W.; Molefe, M. N.; Frost, J. W. "Microbial
Synthesis of the Energetic Material Precursor 1,2,4-Butanetriol."
J. Am. Chem. Soc. 2003, 125, 12998. |
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| Guo, J.; Frost, J. W. "Biosynthesis
of 1-Deoxy-1-imino-D-erythrose 4-Phosphate: A Defining
Metabolite in the Aminoshikimate Pathway." J. Am.
Chem. Soc. 2002, 124, 528. |
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| Hansen, C.; Frost, J. W. "Deoxygenation of Polyhydroxybenzenes
Derived from Glucose: An Alternative Strategy for
the Benzene-Free Synthesis of Aromatic Chemicals."
J. Am. Chem. Soc. 2002, 124, 5926. |
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| Niu, W.; Draths, K. M.; Frost,
J. W. "Benzene-Free Synthesis of Adipic Acid." Biotechnol.
Prog. 2002, 18, 201. |
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| Guo, J.; Frost, J. W. "Kanosamine Biosynthesis:
A Likely Source of the Aminoshikimate Pathway's Nitrogen
Atom." J. Am. Chem. Soc. 2002, 124, 10642. |
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| Yi, J.; Li, K.; Draths, K. M.;
Frost, J. W. "Modulation of Phosphoenolpyruvate Synthase
Expression Increases Shikimate Pathway Product Yields
in E. coli". Biotechnol. Prog. 2002, 18, 1141. |
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| Chandran, S. C.; Frost, J. W. "Aromatic Inhibitors
of Dehydroquinate Synthase: Synthesis, Evaluation
and Implications for Gallic Acid Biosynthesis." Bioorg.
Med. Chem. Lett. 2001, 11, 1493. |
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| Gibson, J. M.; Thomas, P. S.;
Thomas, J. D.; Barker, J. L.; Chandran, S. S.; Harrup,
Draths, K. M.; Frost, J. W. "Benzene-Free Synthesis
of Phenol." Angew. Chemie, Int. Ed. 2001, 40, 1945. |
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| Barker, J. L.; Frost, J. W. "Microbial Synthesis
of p-Hydroxybenzoic Acid from Glucose." Biotechnol.
Bioeng. 2001, 76, 376. |
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| Knop, D. R.; Draths, K. M.; Chandran,
S. S; Barker, J. L.; von Daeniken, R.;Weber, W.; Frost,
J. W. "Hydroaromatic Equilibration During Biosynthesis
of Shikimic Acid." J. Am. Chem. Soc. 2001, 123, 10173. |
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| Ran, N.; Knop, D. R.; Draths, K. M.; Frost, J. W.
"Benzene-Free Synthesis of Hydroquinone." J. Am. Chem.
Soc. 2001, 123, 10927. |
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| Kambourakis, S.; Frost, J. W.
"Synthesis of Gallic Acid: Cu+2-Mediated Oxidation
of 3-Dehydroshikimic Acid." J. Org. Chem. 2000, 65,
6904. |
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| Kambourakis, S.; Draths, K. M.; Frost, J. W. "Synthesis
of Gallic Acid and Pyrogallol from Glucose: Replacing
Natural Product Isolation with Microbial Catalysis."
J. Am. Chem. Soc. 2000, 122, 9042. |
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| Li, K.; Mikola, M. R.; Draths,
K. M.; Worden, R. M.; Frost, J. W. "Fed-Batch Fermentor
Synthesis of 3-Dehydroshikimic Acid Using Recombinant
Escherichia coli ." Biotechnol. Bioeng. 1999, 64, 61. |
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| Draths, K. M.; Knop, D. R.; Frost, J. W. "Shikimic
Acid and Quinic Acid: Replacing Isolation from Plant
Sources with Recombinant Microbial Biocatalysis."
J. Am. Chem. Soc. 1999, 121, 1603. |
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| Hansen, C. A.; Dean, A. B.; Draths,
K. M.; Frost, J. W. "Synthesis of 1,2,3,4-Tetrahydroxybenzenes
from Glucose via myo-Inositol Intermediacy." J. Am.
Chem. Soc. 1999, 121, 3799. |
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| Tian, F.; Migaud, M. E.; Frost, J. W. "myo-Inositol
1-Phosphate Synthase: Does a Single Active-Site Amino
Acid Catalyze Multiple Proton Transfers." J. Am. Chem.
Soc. 1999, 121, 5795. |
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| Li, K.; Frost, J. W. "Microbial
Synthesis of 3-Dehydroshikimic Acid: A Comparative
Analysis of D-Xylose, L-Arabinose, and D-Glucose Carbon
Sources." Biotechnol. Prog. 1999, 15, 876. |
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| Li, K.; Frost, J. W. "Succinic Acid as a Proform
of Phosphoenolpyruvic Acid: Employing Glucose Adjuncts
in Microbe-Catalyzed Synthesis." J. Am. Chem. Soc.
1999, 121, 9461. |
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| Carpenter, E. P.; Hawkins, A.
R.; Frost, J. W.; Brown, K. A. "Crystal Structure
of Dehydroquinate Synthase: One Active Site Catalyzes
Multiple Chemical Reactions." Nature 1998, 394, 299. |
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| Li, K.; Frost, J. W. "Synthesis of Vanillin from
D-Glucose." J. Am. Chem. Soc. 1998, 120, 10545. |
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| Montchamp, J.-L.; Frost, J. W.
"Cyclohexenyl and Cyclohexylidene Inhibitors of 3-Dehydroquinate
Synthase: Active Site Interactions Relevant to Enzyme
Mechanism and Inhibitor Design." J. Am. Chem. Soc.
1997, 119, 7645. |
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| Migaud, M. E.; Frost, J. W. "Elaboration of a General
Strategy for Inhibition of MIP Synthase: Active Site
Interactions of Analogues Possessing Oxidized Reaction
Centers." J. Am. Chem. Soc. 1996, 118, 495. |
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| Chee-Sanford, J. C.; Frost, J.
W.; Fries, M. R.; Zhou, J.; Tiedje, J. M "Evidence
for Acetyl Coenzyme A and Cinnamoyl Coenzyme A in
the Anaerobic Toluene Mineralization Pathway in Azoracus tolulyticus Tol-4." Appl. Environ. Microbiol. 1996,
62, 964. |
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| Migaud, M. E.; Chee-Sanford, J. C.; Tiedje, J. M.;
Frost, J. W. "Benzylfumaric, Benzylmaleic, and Z-
and E-Phenylitaconic Acids: Synthesis, Characterization,
and Correlation with a Metabolite Generated by Azoarcus
tolulyticus Tol-4 during Anaerobic Toluene Degradation."
Appl. Environ. Microbiol. 1996, 62, 974. |
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| Montchamp, J.-L.; Tian, F.; Hart,
M. E.; Frost, J. W. "2,3-Butane Bisacetal Protection
of Vicinal Diequatorial Diols." J. Org. Chem. 1996,
61, 3897. |
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| Snell, K. D.; Draths, K. M.; Frost, J. W. "Synthetic
Modification of the Escherichia coli Chromosome:
Enhancing the Biocatalytic Conversion of Glucose into
Aromatic Chemicals." J. Am. Chem. Soc. 1996, 118,
5605. |
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| Frost, J. W. "Renewable Feedstocks."
Chem. Eng. 1996, May 16 (611), 32. |
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| Tian, F.; Montchamp, J.-L.; Frost, J. W. "Inhibitor
Ionization as a Determinant of Binding to 3-Dehydroquinate
Synthase." J. Org. Chem. 1996, 61, 7373. |
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| Richman, J. E.; Chang, Y.-C.;
Kambourakis, S.; Draths, K. M.; Almy, E.; Snell, K.
D.; Strasburg, G. M.; Frost, J. W. "Reaction of 3-Dehydroshikimic
Acid with Molecular Oxygen and Hydrogen Peroxide:
Products, Mechanism, and Associated Antioxidant Activity."
J. Am. Chem. Soc. 1996, 118, 11587. |
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| Frost, J. W.; Draths, K. M. "Sweetening Chemical
Manufacture." Chemistry in Britain 1995, 31, 206. |
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| Draths, K. M.; Frost, J. W. "Environmentally
Compatible Synthesis of Catechol from D-Glucose."
J. Am. Chem. Soc. 1995, 117, 2395. |
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| Migaud, M. E.; Frost, J. W. "Inhibition of myo-Inositol-1-phosphate
Synthase by a Reaction Coordinate Intermediate." J.
Am. Chem. Soc. 1995, 117, 5154. |
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| Montchamp, J.-L.; Tian, F.; Frost,
J. W. "Double Arbuzov Reaction of in Situ Generated
Bis(trimethylsiloxy)phosphine with Dielectrophiles:
Methodology for the Synthesis of Cyclic Phosphinic
Acids." J. Org. Chem. 1995, 60, 6076. |
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| Frost, J. W.; Draths, K. M. "Biocatalytic Syntheses
of Aromatics from D-Glucose: Renewable Microbial Sources
of Aromatic Compounds." Ann. Rev. Microbiol. 1995,
49, 557. |
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| Frost, J. W.; Lievense, J. "Prospects
for Biocatalytic Synthesis of Aromatics in the 21st
Century." New J. Chem. 1994, 18, 341. |
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| Draths, K. M.; Frost, J. W. "Environmentally Compatible
Synthesis of Adipic Acid from D-Glucose." J. Am. Chem.
Soc. 1994, 116, 399. |
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| Dudley, M. W.; Frost, J. W. "Biocatalytic
Desulfurization of Arylsulfonates." Bioorg. Med. Chem.
1994, 2, 681. |
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| Montchamp, J.-L.; Peng, J.; Frost, J. W. "Inversion
of an Asymmetric Center in Carbocyclic Inhibitors
of 3-Dehydroquinate Synthase: Examining and Exploiting
the Mechanism for syn-Elimination During
Substrate Turnover." J. Org. Chem. 1994, 59, 6999. |
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| Montchamp, J.-L.; Frost, J. W.
"Synthesis and Evaluation of 3-Dehydroquinate Synthase
Transition State Analogues." J. Org. Chem. 1994, 59,
7596. |
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| Montchamp, J.-L.; Piehler, L. T.; Tolbert, T. J.;
Frost, J. W. "Designing Inhibitors of Dehydroquinate
Synthase: Structural Simplicity Versus Inhibitory
Potency." Bioorg. Med. Chem. Lett. 1993, 3, 1403. |
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| Dell, K. A.; Frost, J. W. "Identification
and Removal of Impediments to Biocatalytic Synthesis
of Aromatics from D-Glucose: Rate-Limiting Enzymes
in the Common Pathway of Aromatic Amino Acid Biosynthesis."
J. Am. Chem. Soc. 1993, 115, 11581. |
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| Montchamp, J.-L.; Migaud, M. E.; Frost, J. W. "Phosphonomethylation
of Cyclohexene Oxides." J. Org. Chem. 1993, 58, 7679. |
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| Draths, K. M.; Pompliano, D. L.;
Conley, D. L.; Frost, J. W.; Berry, A.; Disbrow, G.;
Starversky, R.; Lievense, J. "Biocatalytic Synthesis
of Aromatics from D-Glucose: The Role of Transketolase."
J. Am. Chem. Soc. 1992, 114, 3956. |
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| Montchamp, J.-L.; Piehler, L. T.; Frost, J. W. "Diastereoselection
and In Vivo Inhibition of 3-Dehydroquinate Synthase."
J. Am. Chem. Soc. 1992, 114, 4453. |
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| Montchamp, Jean-Luc; Piehler,
L. T.; Tolbert, T. J. "The Basis for Slowly Reversible
Inhibition of Dehydroquinate Synthase: A Case of Mistaken
Identity?" Bioorg. Med. Chem. Lett. 1992, 2, 1349. |
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| Draths, K. M.; Frost, J. W. "Combining Biocatalysis
with Nineteenth Century Organic Chemistry: Conversion
of D-Glucose into Quinoid Organics." J. Am. Chem.
Soc. 1992, 114, 9725. |
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| Avila, L. Z.; Bishop, P. A.; Frost,
J. W. "Hydrocarbon and Phosphate Triester Formation
During Homolytic Hydrolysis of Organophosphonium Ions:
An Alternate Model for Organophosphonate Biodegradation."
J. Am. Chem. Soc. 1991, 113, 2242. |
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| Piehler, L. T.; Montchamp, J.-L.; Frost, J. W.;
Manly, C. J. "Predicting Inhibition of Dehydroquinate
Synthase." Tetrahedron 1991, 47, 2423. |
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| Avila, L. Z.; Draths, K. M.; Frost,
J. W. "Metabolites Associated with Organophosphonate
C-P Bond Cleavage: Chemical Synthesis and Microbial
Degradation of [32P]-Ethylphosphonic Acid." Bioorg.
Med. Chem. Lett. 1991, 1, 51. |
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| Montchamp, J.-L.; Frost, J. W. "Irreversible Inhibition
of 3-Dehydroquinate Synthase." J. Am. Chem. Soc. 1991,
113, 6296. |
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| Draths, K. M.; Frost, J. W. "Conversion
of D-Glucose into Catechol: The Not-So-Common Pathway
of Aromatic Biosynthesis." J. Am. Chem. Soc. 1991,
113, 9361. |
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| Draths, K. M.; Frost, J. W. "Synthesis Using Plasmid-Based
Biocatalysis: Plasmid Assembly and 3-Deoxy-D-arabino-heptulosonate
Production." J. Am. Chem. Soc. 1990, 112, 1657. |
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| Draths, K. M.; Frost, J. W. "Genomic
Direction of Synthesis During Plasmid-Based Biocatalysis."
J. Am. Chem. Soc. 1990, 112, 9630. |
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| Myrvold, S.; Reimer, L. M.; Pompliano, D. L.; Frost,
J. W. "Chemical Inhibition of Dehydroquinate Synthase."
J. Am. Chem. Soc. 1989, 111, 1861. |
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| Pompliano, D. L.; Reimer, L. M.;
Myrvold, S.; Frost, J. W. "Probing Lethal Metabolic
Perturbations in Plants with Chemical Inhibition of
Dehydroquinate Synthase." J. Am. Chem. Soc. 1989,
111, 1866. |
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| Avila, L. Z.; Frost, J. W. "Phosphonium Ion Fragmentations
Relevant to Organophosphonate Biodegradation." J.
Am. Chem. Soc. 1989, 111, 8969. |
|
| Avila, L. Z.; Frost, J. W. "Monomeric
Metaphosphate Formation During Radical-Based Dephosphorylation."
J. Am. Chem. Soc. 1988, 110, 7904. |
|
| Frost, J. W.; Loo, S.; Cordeiro, M. L.; Li, D. "Radical-based
Dephosphorylation and Organophosphonate Biodegradation."
J. Am. Chem. Soc. 1987, 109, 2166. |
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| Mehdi, S.; Frost, J. W.; Knowles,
J. R. "Dehydroquinate Synthase from Escherichia
coli and its Substrate 3-Deoxy-D-arabino-heptulosonic
Acid 7-Phosphate." Meth. Enzymol. 1987, 142, 306. |
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| Roach, M.; Ungar, L. W.; Zare, R. N.; Reimer, L.
M.; Pompliano, D. L.; Frost, J. W. "Sensitive Fluorescence
Detection of Alkylphosphonic Acids Using p-(9-Anthroyloxy)
phenacyl Bromide." Analyt. Chem. 1987, 59, 1056. |
|
| Avila, L. Z.; Loo, S. H.; Frost,
J. W. "Chemical and Mutagenic Analysis of Aminomethylphosphonate
Biodegradation." J. Am. Chem. Soc. 1987, 109, 6758. |
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| Loo, S. H.; Peters, N. K.; Frost, J. W. "Genetic
Characterization of an Escherichia coli Mutant Deficient
in Organophosphonate Biodegradation." Biochem. Biophys.
Res. Comm. 1987, 148, 148. |
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| Cordeiro, M. L.; Pompliano, D.
L.; Frost, J. W. "Degradation and Detoxification of
Organophosphonates: Cleavage of the Carbon to Phosphorus
Bond." J. Am. Chem. Soc. 1986, 108, 332. |
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| Reimer, L. M.; Conley, D. L.; Pompliano, D. L.;
Frost, J. W. "Construction of an Enzyme-Targeted Organophosphonate
Using Immobilized Enzyme and Whole Cell Synthesis."
J. Am. Chem. Soc. 1986, 108, 8010. |
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| Peters, N. K.; Frost, J. W.; Long,
S. R. "A plant flavone, luteolin, induces expression
of Rhizobium meliotii nodulation genes." Science 1986,
223, 977. |
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| Frost, J. W.; Bender, J. L.; Kadonaga, J. T.; Knowles,
J. R. "Dehydroquinate Synthase: Purification, Cloning,
and the Construction of E. coli Overproducers
of the Enzyme." Biochemistry 1984, 23, 4470. |
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| Frost, J. W.; Knowles, J. R. "3-Deoxy-D-arabino-heptulosonic
acid 7-phosphate: Chemical Synthesis and Isolation
from Escherichia coli Auxotrophs."
Biochemistry 1984, 23, 4465. |
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| Frost, J. W. "5-Thio-D-glucose: How Do Enzymes Work?"
Aldrichim. Acta 1983, 16, 3. |
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| Frost, J. W.; Rastetter, W. H.
"Flavoprotein Monooxygenases: A Chemical Model." J.
Am. Chem. Soc. 1981, 103, 5242. |
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| Frost, J. W.; Rastetter, W. H. "Biomimetic 8-alpha
Functionalization of Riboflavin." J. Am. Chem. Soc.
1980, 102, 7157. |
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| Feuer, H.; Blecker, L. R.; Jans,
Jr., R. W.; Frost, J. W. "Alkyl Nitrate Nitration
of Active Methylene Compounds." J. Heterocyclic Chem.
1979, 16, 481. |
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| Rastetter, W. H.; Gadek, T. R.; Tane, J. P.; Frost,
J. W. "Oxidations and Oxygen Transfers Effected by
a Flavin N(5)-Oxide. A Model for Flavin-Dependent
Monooxygenases." J. Am. Chem. Soc. 1979, 101, 2228. |
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| Rastetter, W. H.; Adams, J.; Frost,
J. W.; Nummy, L. J.; Frommer, J. E.; Roberts, K. B.
"On the Involvement of Lipoic Acid in Alpha-Keto Acid
Dehydrogenase Complexes." J. Am. Chem. Soc. 1979,
101, 2752. |
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| Rastetter, W. H.; Frost, J. W. "Oxaziridines and
Oxygen Transfer." Tetrahedron Lett. 1979, 3353. |
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